Bromantane (Ladasten) is a drug that purportedly improves physical and mental performance. It may help relieve fatigue and anxiety, enhance learning, and help with physical activity. But there are a couple of side effects associated with this medication, and there aren’t many human studies out there. Keep reading to learn about bromantane’s positives and negatives.
Disclaimer: This post is not a recommendation or endorsement for the use of bromantane. The FDA has not approved this medication for any specific medical or alternative use, and also the available research on it’s still in a very early stage, without adequate data to come to any firm decisions about its overall efficacy or safety in human users. We’ve composed this post for informational purposes only, and our aim is solely to inform people about what science now says about bromantane’s mechanics, possible consequences, and possible side-effects.
What Is Bromantane?
Bromantane/bromantan (Ladasten) is a medication manufactured in Russia in the 1980s. Derived from adamantane, bromantane is a facto protector, that can be a kind of drug that enhances physical activity under extreme environmental conditions (such as low oxygen or high fever).
Bromantane purportedly increases vitality, reduces anxiety, inhibits tiredness, encourages learning, and enhances movement coordination. Each of these effects is claimed to unite to help increase both mental and physical performance. Back in Russia, bromantane has been approved for the treatment of neurasthenia.
It doesn’t possess any addictive possible and doesn’t have any severe side effects in line with the limited scientific study.
However, it’s banned from many sports competitions, such as the Olympics.
Mechanism of Action
Though bromantane’s precise mechanism is unknown, scientists believe that it operates by increasing brain activity (in the hippocampus, hypothalamus nuclei, as well as the reticular nuclei of the operculum).
It acts via the dopamine program, by raising tyrosine hydroxylase and amino acid decarboxylase. This, consequently, increases dopamine formation from tyrosine.
By boosting dopamine, bromantane may boost alertness and wakefulness.
Bromantane also raises serotonin from the mind, which might help raise feelings of pleasure.
There’s absolutely no evidence of bromantane’s effects on human genes.
In rats, bromantane government to rats raised:
- HIF1A, which helps the body adapt to reduced oxygen levels.
- ADRl (alcohol dehydrogenase), which helps with alcohol retrieval.
- SAA, that controls amyloid-beta precursor protein. This protein is related to an increased risk of Alzheimer’s disease.
Uses of Bromantane
Maybe Effective for:
Neurasthenia is a condition characterized by fatigue, headache, psychological weariness, and sleeplessness.
In a month-long analysis of over 700 individuals suffering from neurasthenia, 50 and 100 mg doses of bromantane helped reduce symptoms and improved their sleep. Additionally, it improved their quality of life and just 3 percent of those patients experienced minor side effects.
In a different month-long analysis of neurasthenia patients, bromantane reduced their symptoms.
Bromantane also affected brain activity amounts in another study of individuals with this condition. People with high alpha waves had improved low-beta waves and decreased high-beta waves, while the reverse was true in those with low alpha waves.
This implies that bromantane will wake you up if you are tired and increase consciousness if you are awake. Consult with your doctor if bromantane can assist with neurasthenia on your circumstance.
Insufficient Evidence for:
Improving Brain Function
In a study of 10 healthy subjects, bromantane enhanced productivity, vigilance, and motor performance (motion and coordination).
Two clinical trials and a study in rats showed that bromantane reduced stress.
By boosting dopamine and serotonin in rat brains, bromantane increased alertness and wakefulness.
In a rat study, bromantane enhanced short-term memory, motivation, planning skills, and attention.
In rats, bromantane enhanced brain action. However, at excessive doses, it may inhibit acetylcholine pathways.
Bromantane given to female rats also benefited their offspring at another rat study. The infant rats developed reflexes faster compared to other rats, but their growth development differences were insignificant.
Taken together, the evidence is insufficient to support the part of the bromantane as a cognitive enhancer. Larger, stronger clinical trials are required to confirm these preliminary findings.
Animal Research (Lack of Proof)
No clinical evidence supports using bromantane for any of the conditions listed within this part. Below is a list of the existing creature and cell-based research, which ought to guide further investigational efforts. However, the research recorded should not be interpreted as supportive of any health advantage.
Enhancing Physical Activity
In rats, bromantane marginally increased adrenaline and noradrenaline’s effects. It retained adrenaline and noradrenaline in the bloodstream instead of departing the body via urine, thus assisting with physical activity.
Rats performed more efficiently during treadmills and swimming tests when given bromantane.
Bromantane also increased the blood flow from the hearts of rats.
In mice, bromantane reduced depression-induced inflammation. It diminished the levels of the next inflammatory cytokines:
In rats, bromantane assisted excite the immune system during stressful states. It enhanced their resistance to toxic agents. Bromantane also increased immune cells (B-cell levels). This will help during exhaustion healing, high environmental temperatures, and reduced oxygen conditions.
In male mice, bromantane management increased sperm count and sperm motion. Additionally, it helped reduce embryo loss in female mice.
In addition, 3 days of bromantane treatment improved the rats’ sex drive (desire for sexual activity). This dose-dependent effect may be brought about by the rise in dopamine action.
Supplementing with Bromantane
Since bromantane is not approved by the FDA for almost any conditions and has been tested in only a few clinical trials, there isn’t any official dosing information accessible. Users and nutritional supplement manufacturers have created unofficial doses according to trial and error. Talk to your physician before supplementing with bromantane.
According to user reviews, regular doses are 50 to 100 milligrams per day, although athletes might dose higher. Some users reported unwanted effects following 3,000 mg.
Bromantane stays in the body for a long time, and may still be present in the blood 2 weeks after use.
Bromantane reduced pain sensitivity in mice, but only at extremely substantial levels (300 to 600 mg/kg).
Also, bromantane may stimulate cytochrome P-450 production, which aids with detoxifying the liver.
Side Effects and Risks
Because bromantane is an insufficiently researched substance, its safety profile is comparatively unknown. You need to consult your doctor about potential side effects based on your health condition and potential drug or supplement interactions.
Bromantane has not yet been reported to cause any withdrawal symptoms or addiction.
In animals, high doses caused:
- Increased urination
Some users report fatigue, depression, and brain fog after taking this drug.
Limitations and Caveats
Although the results from animal studies appear promising, not much scientific evidence is available about bromantane’s effects on people. The number of human clinical trials that are offered are funded by the drug business, written only in Russian (thus preventing us from accessing their specifics to get a critical analysis), or even both.
More studies are required before bromantane can be safely used for any of its purported health effects.
The opinions expressed in this section are solely those of bromantane users, who may or may not have medical or scientific training. Their testimonials don’t reflect the opinions of SelfHacked. SelfHacked does not endorse any specific solution, service, or treatment.
Don’t consider user adventures as medical advice. Never delay or disregard seeking professional medical advice from your health care provider or another professional health care provider because of something you’ve read on SelfHacked. We know that reading person, real-life encounters can be a very helpful resource, but it’s never a replacement for professional medical advice, diagnosis, or therapy from a qualified healthcare provider.
After regularly dosing bromantane for each week, an individual reported that his motivation, energy levels, and the pleasure increased. The user thought it helped with his low dopamine levels. It was not like other stimulants that have an instant effect but mandatory repeated doses. However, he warned that users must measure the doses accurately and not overdose.
Another user believed bromantane the most effective nootropic he’d tried, and reported he gave him plenty of power to go during the day. Unfortunately, it gave him too much energy and forced him barely able to drop asleep.
Others also praised its anti-anxiety and antidepressive effects.
Although there is no scientific evidence available, many users claimed that bromantane helped improve Alzheimer’s and ADHD symptoms.